Crosslinking, Labeling and Protein Modification
STA Pharmaceutical Fmoc-amino-PEG3-CH2COOH | 50 g | CAS 139338-72-0 | MDL MFCD13182400
Fmoc-amino-PEG3-CH2COOH is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 50 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 139338-72-0
- MDL: MFCD13182400
- InChIKey: XNOJSAOJCBOZTA-UHFFFAOYSA-N
- Molecular Weight: 429.469
- Molecular Formula: C23H27NO7
- Purity: ≥95%
- Container Type: 250 mL HDPE
- Pack Size: 50 g
- Net Weight: 50 g
- Gross Weight: 89.8 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13-tetraoxa-4-azapentadecan-15-oic acid
- SMILES: O=C(COCCOCCOCCNC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)O
![eMolecules 2112732-03-1 | N-(Azido-PEG3)-N-Boc-PEG3-t-butyl ester | Broadpharm | MFCD30723211 | 578.704 | C26H50N4O10 | 98.000 | CC(C)(C)OC(=O)CCOCCOCCOCCN(CCOCCOCCOCCN=[N+]=[N-])C(=O)OC(C)(C)C | 500mg | 343283639](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502203400.JPG-250.jpg)
eMolecules 2112732-03-1 | N-(Azido-PEG3)-N-Boc-PEG3-t-butyl ester | Broadpharm | MFCD30723211 | 578.704 | C26H50N4O10 | 98.000 | CC(C)(C)OC(=O)CCOCCOCCOCCN(CCOCCOCCOCCN=[N+]=[N-])C(=O)OC(C)(C)C | 500mg | 343283639
N-(Azido-PEG3)-N-Boc-PEG3-t-butyl ester | Broadpharm | 2112732-03-1 | MFCD30723211 | 578.704 | C26H50N4O10 | 98.000 | CC(C)(C)OC(=O)CCOCCOCCOCCN(CCOCCOCCOCCN=[N+]=[N-])C(=O)OC(C)(C)C | 500mg | 343283639
Medchemexpress LLC Mal-amido-PEG6-NHS ester | 1137109-21-7 | 98.76% | 601.60 | 1 G
Mal-amido-PEG6-NHS ester is a PEG-based PROTAC linker that can be utilized in the synthesis of PROTACs. PROTACs themselves consist of two different ligands linked together; one ligand targets an E3 ubiquitin ligase, and the other targets the protein intended for degradation. This mechanism exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
Medchemexpress LLC 5,8,11,14-tetraoxa-2-azahexadecanedioic acid, 1-(1,1-dimethylethyl) ester | 876345-13-0 | MFCD30528568 | ≥97.0% | 351.39 g/mol | C15H29NO8 | 1 G
Boc-NH-PEG4-CH2COOH is a Boc-protected polyethylene glycol (PEG4) linker terminating in a carboxylic acid, used as a cleavable linker in conjugation chemistry and in the synthesis of PROTACs and antibody-drug conjugates.
- Cleavable Boc-protected PEG4 linker suitable for conjugation chemistry.
- Terminal carboxylic acid compatible with amide coupling reactions.
- High purity (≥97.0%) and molecular weight 351.39 g/mol.
- Available as a 1 g unit; other pack sizes are offered for synthetic applications.
- Store pure material at -20°C; stability in solvent is limited and temperature dependent.
Medchemexpress LLC Hydroxy-PEG4-CH2COOH | 70678-95-4 | 97.0% | C10H20O7 | 100 MG
Hydroxy-PEG4-CH2COOH is a PEG-based PROTAC linker essential for the synthesis of PROTACs. These molecules are designed with two distinct ligands connected by a linker, one targeting an E3 ubiquitin ligase and the other binding to a specific target protein. This design enables the selective degradation of target proteins by harnessing the intracellular ubiquitin-proteasome system.
- PEG-based linker
- Essential for PROTAC synthesis
- Features two distinct ligands connected by a linker
- Targets an E3 ubiquitin ligase
- Binds to a specific target protein
- Enables selective degradation of target proteins
- Utilizes the ubiquitin-proteasome system
Cayman Chemical Gefitinib-based PROTAC 3 5mg
A PROTAC comprised of gefitinib linked to VHL ligand 1; induces degradation of EGFR containing the activating mutation L858R or an exon 19 deletion (DC50s = 22.3 and 11.7 nM, respectively) but does not induce degradation of wild-type EGFR at ≤10 μM in cell-based assays
Medchemexpress LLC Biotin-PEG2-alkyne | 2227450-68-0 | MFCD31922733 | 95.6% | 369.48 | C17H27N3O4S | 25 MG
Biotin-PEG2-alkyne is a short polyethylene glycol (PEG2) linker that contains a biotin moiety and a terminal alkyne. It is designed for affinity capture and labeling workflows and is compatible with copper(I)-catalyzed azide-alkyne cycloaddition (click chemistry). Supplied as a 25 mg solid with typical purity of 95.6%, it is intended for bioconjugation and chemical biology applications.
- Enables biotinylation via copper(I)-catalyzed azide-alkyne cycloaddition.
- Provides a short PEG2 spacer to reduce steric hindrance.
- Suitable for affinity capture, pull-downs, and labeling workflows.
- Off-white to light yellow solid, easy to store and handle.
- Stable when stored as powder at -20°C or 4°C according to recommended conditions.
=O)([H])COP(O)(OCCNC(OCCNC(NC1=CC(C2(C(C=CC(O)=C3)=C3OC4=C2C=CC(O)=C4)OC5=O)=C5C=C1)=S)=O)=O.[n] | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000281005.png-250.jpg)
Medchemexpress LLC Dspe-peg-fitc | 1000788-53-3 | 98.1% | 5,000 (average) | O=C(CCCCCCCCCCCCCCCCCCC)OC[C@](OC(CCCCCCCCCCCCCCCCCCC)=O)([H])COP(O)(OCCNC(OCCNC(NC1=CC(C2(C(C=CC(O)=C3)=C3OC4=C2C=CC(O)=C4)OC5=O)=C5C=C1)=S)=O)=O.[n] | 5 MG
A fluorescein-labeled PEGylated phospholipid with a DSPE lipid anchor and an average PEG molecular weight of 5,000. It is designed to incorporate into lipid bilayers or decorate nanoparticle surfaces to provide stable green fluorescence for imaging, tracking, and surface-labeling applications in vitro and in vivo studies.
- Provides stable fluorescein (FITC) green fluorescence for imaging and tracking.
- Incorporates into lipid bilayers via a DSPE lipid anchor.
- PEG spacer (average MW 5,000) reduces nonspecific adsorption and improves colloidal stability.
- Enables surface labeling of liposomes, micelles, and nanoparticles.
- Supplied as a purified material with documented purity by HPLC.
Medchemexpress LLC Dspe-m-peg-nhs | 99.4% | 3,400 Da (average) | 25 MG
DSPE-m-PEG-NHS (MW 3400) is a PEGylated phospholipid with an N-hydroxysuccinimide (NHS) activated ester on the PEG terminus. Supplied as a powder with an average molecular weight of approximately 3,400 Da, it is used to introduce PEG-lipid functionality into liposomes and lipid nanoparticles and to enable covalent attachment of amine-containing ligands for targeted delivery and surface modification.
- NHS-activated ester for efficient amide bond formation with primary amines.
- Average molecular weight approximately 3,400 Da for predictable PEG length.
- Powder form suitable for storage under frozen conditions.
- Compatible with liposome and lipid nanoparticle formulation workflows.
- Enables surface conjugation of proteins, peptides, or antibodies.
- High purity to support reproducible formulation and conjugation performance.
![eMolecules N-bis(Azido-PEG10)-N-(PEG10-t-butyl ester) | Broadpharm |1604.926 | C71H141N7O32 | 95.000 | CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-] | 50mg | 599128873](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502475851.JPG-250.jpg)
eMolecules N-bis(Azido-PEG10)-N-(PEG10-t-butyl ester) | Broadpharm |1604.926 | C71H141N7O32 | 95.000 | CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-] | 50mg | 599128873
N-bis(Azido-PEG10)-N-(PEG10-t-butyl ester) | Broadpharm |1604.926 | C71H141N7O32 | 95.000 | CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-] | 50mg | 599128873
Medchemexpress LLC Mal-amido-(CH2COOH)2 | 207613-14-7 | 99.2% | 284.22 g/mol | C11H12N2O7 | 5 MG
Mal-amido-(CH2COOH)2 is a maleimidoethyl-containing intermediate used in the synthesis of hydrophilic antibody-drug conjugate (ADC) linkers. It is provided as a research-use building block for linker chemistry.
- Maleimidoethyl intermediate for ADC linker synthesis.
- High reported purity supports consistent chemical performance.
- Moderate molecular weight and polar functionality aid solubility in common organic solvents.
- Reactive maleimide moiety enables conjugation to thiol-containing biomolecules.
- Available in small research-scale quantities suitable for route development and linker optimization.
Medchemexpress LLC 4,7,10,13-Tetraoxahexadecanediamide, N1,N16-bis[3-(11,12-didehydrodibenz[b,f]azocin-5(6H) | 2182601-68-7 | 97.4% | 100 MG
DBCO-PEG4-DBCO is a versatile PEG-based PROTAC linker used in the synthesis of PROTACs. It also serves as a cleavable ADC linker for antibody-drug conjugate (ADC) synthesis. As a click chemistry reagent, it features a DBCO group that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules.
- Functions as a PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Serves as a cleavable ADC linker
- Enables synthesis of antibody-drug conjugates (ADCs)
- Acts as a click chemistry reagent
- Contains a DBCO group for SPAAC reactions
eMolecules DBCO-PEG4-PFP ester | Broadpharm |718.674 | C36H35F5N2O8 | 98.000 | Fc1c(F)c(F)c(OC(=O)CCOCCOCCOCCOCCNC(=O)CCC(=O)N2Cc3ccccc3C#Cc3ccccc23)c(F)c1F | 100mg | 411413975
DBCO-PEG4-PFP ester | Broadpharm |718.674 | C36H35F5N2O8 | 98.000 | Fc1c(F)c(F)c(OC(=O)CCOCCOCCOCCOCCNC(=O)CCC(=O)N2Cc3ccccc3C#Cc3ccccc23)c(F)c1F | 100mg | 411413975